Jeff Foxlove, an expert advertising copywriter, is employed by The Cudmore Agency, known for producing crude, disgusting, and raunchy advertising campaigns. Jeff has no qualms about wading into the muck. He earns a respectable wage and has the interest of an aspiring but dimwitted actress. Without a doubt, Jeff is living his ideal life.

Jeff receives a vicious bite from a spooky, wild creature of the night while he is on vacation and exploring the Yucatan jungle at night under the light of the moon. After defeating the beast, he is shocked to see that his injuries have miraculously healed and that the attack from the previous night has vanished the following day. When Jeff returns to New York to restart his life, he endures the agony of a terrible metamorphosis on the night of the next full moon. The full moon’s magic has turned him into a werewolf.

“Werewolf On Madison Avenue” follows Jeff’s journey as a werewolf and the man behind a wildly successful new ad campaign. As he becomes increasingly desperate to lift the curse of lycanthropy, Jeff realizes his only hope is to return to the Yucatan jungle in search of a miracle cure.